Article

OBJECTIVE: To examine exercise testing response in Alzheimer's disease (AD) and
possible disease-related change over time. DESIGN: Retrospective assessment of a
2-year observational study. SETTING: University medical center. PARTICIPANTS:
Individuals without dementia (n=50) and with AD (n=31). INTERVENTIONS: Not
applicable. MAIN OUTCOME MEASURES: Participants underwent a clinical dementia
evaluation and performed an incremental exercise test using a treadmill and the
modified Bruce protocol at baseline and at a 2-year follow-up. We examined oxygen
consumption, minute ventilation, heart rate, and ventilatory equivalents for
oxygen and carbon dioxide at submaximal and peak exercise intensities to
determine whether the measures were different between groups or over time.
RESULTS: Participants with AD and those without dementia performed similarly at
submaximal effort, and both groups showed similar changes in exercise response
over 2 years. However, nondemented individuals had consistently higher values of
oxygen consumption (P</=.02) and minute ventilation at peak effort at baseline
(P=.003). CONCLUSIONS: Individuals with AD demonstrate physiologic responses to
submaximal exercise effort that are not significantly different than individuals
without dementia. However, differences are apparent at the extreme of effort.
CI - Copyright (c) 2011 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS