Article

Reactive oxygen species (ROS) are well recognised for playing a dual role as both
deleterious and beneficial species. They are normally generated by tightly
regulated enzymes. ROS overproduction arises either from mitochondrial electron
transport chain or excessive stimulation of NAD(P)H resulting in oxidative
stress, a deleterious process that can be an important mediator of damage to cell
structures (lipids, membranes, proteins, and DNA). However, ROS could have a
beneficial affect at low/moderate concentrations. Physiological roles in cellular
responses to noxia have been reported, in defence against infectious agents, in
the function of a number of cellular signalling pathways, and the induction of a
mitogenic response. The role of ROS in bone metabolism is dual. It is a key
modulator of bone cell function and also implicated in the pathophysiology of
mineral tissues. Elevated production of ROS and/or depletion of antioxidants have
also been observed in a variety of pathological conditions, including
inflammatory joint diseases. Performing physical exercise is associated with
numerous health benefits, playing a role especially in the prevention of bone
loss. However, the production of ROS increases during demanding exercise. To
explore this further, the aim of the present review was to examine bone
remodelling in relation to oxidative stress and exercise.
CI - Copyright (c) 2012 Societe francaise de rhumatologie. Published by Elsevier SAS.
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Langue : ANGLAIS