Article

Skeletal muscle deformity is common in children with spastic cerebral palsy (CP),
but the underlying mechanisms are unclear. This review explores some possible
factors which may influence the development of muscle deformity in CP. Normal
muscle function and growth appear to depend on the interaction of neuronal,
endocrinal, nutritional, and mechanical factors, and also on the development of
an appropriate balance between muscle protein synthesis and degradation, and
between the development of contractile and non-contractile components. In this
context, the changes seen in muscle in children with CP are reviewed and
discussed. It is suggested that the development of muscle deformity in children
with CP may be related to a multifactorial impairment of muscle growth, on which
adaptation of the extracellular matrix due to altered loading may be imposed.
CI - (c) The Authors. Developmental Medicine & Child Neurology (c) 2012 Mac Keith
Press.

Langue : ANGLAIS