Article

AIM: To analyse factors associated with bone density in different skeletal
regions in children with cerebral palsy (CP) of various motor severities.
We examined 56 children with spastic CP (10 diplegia, 12 hemiplegia and 34
quadriplegia) aged 4 to 12 years (35 males, 21 females) and 29 typically
developing children. Children with CP were stratified into three groups based on
Gross Motor Function Classification System (GMFCS) levels I to II (n = 22), III
(n = 8), and IV to V (n = 26). Growth and clinical variables, bone markers,
distal femur and lumbar areal bone mineral density (BMDa), and calcaneal
broadband ultrasound attenuation (BUA) were assessed. RESULTS: The femur BMDa and
calcaneal BUA values were lower in children in low GMFCS levels than in children
in high GMFCS levels (p<0.05; femur BMDa: levels I-III, 0.6-0.7 g/cm(2); levels
IV-V, 0.5 g/cm(2); calcaneal BUA: levels I-II, 39 db/MHz; levels III-V, 20-21
db/MHz). Lumbar BMDa and most bone markers did not differ significantly among CP
and healthy groups. Regression analysis revealed that growth variables and GMFCS
level were mainly associated with lower limb BMDa and BUA, and growth variables
were mainly associated with lumbar BMDa (adjusted r(2) = 0.48-0.56). None of the
bone markers were associated with bone density. INTERPRETATION: Bone densities
vary and are associated with a number of factors in different skeletal regions in
children with CP with a range of motor severities.
CI - (c) The Authors. Journal compilation (c) Mac Keith Press 2010.

Langue : ANGLAIS