Article

AIM: To investigate the association between magnetic resonance imaging (MRI)
patterns and motor function, epileptic episodes, and IQ or developmental quotient
in patients born at term with spastic diplegia. METHOD: Eighty-six patients born
at term with cerebral palsy (CP) and spastic diplegia (54 males, 32 females;
median age 20 y, range 7-42 y) among 829 patients with CP underwent brain MRI
between 1990 and 2008.
The MRI and clinical findings were analysed
retrospectively. Intellectual disability was classified according to the Enjoji
developmental test or the Wechsler Intelligence Scale for Children (3rd edition).
RESULTS: The median ages at diagnosis of CP, assignment of Gross Motor Function
Classification System (GMFCS) level, cognitive assessment, and MRI were 2 years
(range 5 mo-8 y), 6 years (2 y 8 mo-19 y), 6 years (1 y 4 mo-19 y), and 7 years
(10 mo-30 y) respectively. MRI included normal findings (41.9%), periventricular
leukomalacia, hypomyelination, and porencephaly/periventricular venous
infarction. The frequency of patients in GMFCS levels III to V and intellectual
disability did not differ between those with normal and abnormal MRI findings.
Patients with normal MRI findings had significantly fewer epileptic episodes than
those with abnormal ones
(p=0.001). INTERPRETATION: Varied MRI findings, as well
as the presence of severe motor dysfunction and intellectual disability (despite
normal MRI), suggest that patients born at term with spastic diplegia had
heterogeneous and unidentified pathophysiology.
CI - (c) The Authors. Developmental Medicine & Child Neurology (c) 2012 Mac Keith
Press.

Langue : ANGLAIS