Article

A pilot study was conducted to longitudinally quantify effect of
onabotulinum toxin A (BoNT-A) on passive muscle properties in children with
cerebral palsy using ultrasound shear wave elastography. DESIGN: This was a
prospective longitudinal cohort study. RESULTS: Between 1
and 3 mos post-BoNT-A,
a significant improvement in the shear modulus of the lateral gastrocnemius was
found at 10-degrees plantar flexion (PF) (-7.57 [-10.98, -5.07], P = 0.02) and
0-degrees PF (-14.74 [-18.21, -9.38], P = 0.03).
There was a notable, but
nonsignificant, difference in shear modulus at 20-degrees PF, 10-degrees PF, and
0-degrees PF between pre-BoNT-A and 1 mo post-BoNT-A. Pre-BoNT-A shear modulus
was not significantly different from 3 mos post-BoNT-A at all foot positions. No
significant differences in ankle passive range of motion or spasticity were
found. CONCLUSION: Despite no significant change in ankle range of motion or
spasticity, shear wave elastography was able to detect a difference in lateral
gastrocnemius passive muscle properties in children with cerebral palsy after
BoNT-A injections.
The difference in passive muscle properties resolved by 3 mos
post-BoNT-A.

Langue : ANGLAIS