Article

Spinal cord injury (SCI) triggers rapid loss of trabecular bone mineral density
(BMD) in bone epiphyses and a loss of cortical cross-sectional area (CSA) in bone
diaphyses, increasing fracture risk for people with SCI.
The purpose of this
study was to measure trabecular BMD and cortical CSA loss at several previously
unexamined lower-limb sites
(4% fibula, 12% femur, 86% tibia, cortical) in
individuals with SCI. Using peripheral quantitative computed tomography, we
scanned 13 participants with SCI longitudinally and 16 on one occasion; 21
participants without SCI served as controls. In the first year post-SCI, 15% to
35% of BMD was lost at the distal femur, proximal tibia, and distal fibula. Bone
loss at the distal fibula accelerated between 1 and 2 years post-SCI. BMD at
these sites reached a steady state value of ~50% of the non-SCI value 4 years
post-SCI. At the tibia diaphysis, cortical CSA decline was slower, eventually
reaching 65% of the non-SCI value. Because of the extensive loss of bone observed
at these sites, careful consideration needs to be given to the dose of
musculoskeletal stress delivered during rehabilitation interventions like standing, muscle electrical stimulation, and aggressive stretching of spastic muscles.

Langue : ANGLAIS