Article

The aim of this study was to describe the distribution of magnetic resonance
imaging (MRI) patterns in a large population sample of children with cerebral
palsy (CP) and to examine associations between MRI patterns, and antenatal and
perinatal variables. METHOD: Data were retrieved from the Victorian CP Register
for 884 children (527 males, 357 females) born between 1999 and 2006.
Postneonatal MRI was classified for 594 children. For 563 children (329 males,
234 females) for whom classification was to a single MRI pattern, the frequency
of each variable was compared between patterns and with the population frequency.
RESULTS: White matter injury was the most common MRI pattern (45%), followed by
grey matter injury (14%), normal imaging (13%), malformations (10%), focal
vascular insults (9%), and miscellaneous patterns (7%). Parity, birth gestation,
level of neonatal care, Apgar score, and time to established respiration varied
between MRI patterns (p<0.01). Nulliparity was most strongly associated with
focal vascular insults, whereas multiparity was associated only with
malformations. Grey matter injury was not associated with birth in a tertiary
unit, but was strongly associated with severe perinatal compromise. The frequency
of neonatal seizures and of nursery admissions was lowest among children with
malformations. INTERPRETATION: As known risk factors for CP are differentially
associated with specific MRI patterns, future exploration of causal pathways
might be facilitated when performed in pathogenically defined groups.
CI - (c) 2013 Mac Keith Press.

Langue : ANGLAIS