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MR patterns of hypoxic-ischemic brain damage after prenatal, perinatal or postnatal asphyxia
SIE LTL; VANDERKNAAP MS; OOSTING J
NEUROPEDIATRICS , 2000, vol. 31, n° 3, p. 128-136 Doc n°: 99745 Localisation : Documentation IRR Descripteurs : AJ11 - DEVELOPPEMENT DU SYSTEME NERVEUX The relationship between MR patterns of brain damage and type or timing of perinatal hypoxia-ischemia was studied. MR images of 104 children with evidence of bilateral posthypoxic-ischemic brain damage and neonatal records were reviewed. Three different MR patterns were found. Periventricular leukomalacia occurred in 73 children, in 82% after a history of subacute or chronic hypoxia-ischemia, in 71% after preterm birth. Predominant lesions of basal ganglia and thalamus occurred in 21 children, in 95% preceded by acute profound asphyxia, in 85% after term birth. Multicystic encephalopathy occurred in 10 infants, in 70% preceded by mild signs of hypoxia-ischemia, followed by an unexpectedly severe encephalopathy, in 60% after term birth. Statistical analysis showed that the patterns of injury were primarily related to the type of hypoxia-ischemia. We conclude that the type of hypoxia-ischemia, rather than the postconceptional age at occurrence determines the pattern of brain injury. Langue : ANGLAIS Tiré à part : OUI Identifiant basis : 2001215685 |
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