Article

OBJECTIVES: To determine whether systemic inflammation is associated with poor
proprioception; to confirm that systemic inflammation is associated with muscle
weakness; and to determine whether poor proprioception mediates the association
between systemic inflammation and muscle weakness in knee osteoarthritis. DESIGN: Cross-sectional study. SUBJECTS: A total of 689 participants with knee
osteoarthritis from the Amsterdam Osteoarthritis
(AMS-OA) cohort. METHODS:
Systemic inflammation was assessed by erythrocyte sedimentation rate, knee
proprioception by determining the joint motion detection threshold, and muscle
strength with an isokinetic dynamometer. Linear regression models were used to
estimate direct associations between systemic inflammation, proprioception and
muscle strength, and the indirect association (mediation) between systemic
inflammation and muscle strength via proprioception adjusted for potential
confounders. RESULTS: Higher erythrocyte sedimentation rates were associated with
poor proprioception (p = 0.022). Poor proprioception (p < 0.001) and higher
erythrocyte sedimentation rates (p < 0.001) were associated with muscle weakness.
Poor proprio-ception mediated the association between systemic inflammation and
muscle weakness (p = 0.035). CONCLUSION: Results suggest that systemic
inflammation is associated with poor proprioception in knee osteoarthritis. Poor
proprioception may be a path-way through which systemic inflammation is
associated with muscle weakness in patients with knee osteoarthritis.

Langue : ANGLAIS