Article

OBJECTIVES: To investigate the relationships between freezing of gait (FOG) and
activity limitations in ambulant people with Parkinson's disease (PD), and to
explore the contribution of FOG and gait hypokinesia to activity limitations
after adjusting for the effects of disease severity. DESIGN: Retrospective,
cross-sectional design. SETTING: Participants were recruited from neurologists'
clinics and the general public in metropolitan Melbourne, Australia.
Volunteers were screened for eligibility using the following
inclusion criteria: diagnosis of idiopathic PD, modified Hoehn and Yahr stages 0
to IV, without dementia. Participants (N=210) were tested (mean age +/- SD,
67.9+/-9.6y; mean PD duration +/- SD, 6.7+/-5.6y; median Hoehn and Yahr
stage=2.5). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: FOG was
measured using the FOG questionnaire. Gait hypokinesia was quantified using both
the 6-meter walk test and the Timed Up and Go test. Activity limitation was
measured using the modified Unified Parkinson's Disease Rating Scale activities
of daily living (ADL) section and the Schwab and England ADL scale. RESULTS:
Severity of gait freezing correlated significantly with the level of activity
limitation (Spearman correlation coefficient, rho=-.49 to .48; P<.001). A
hierarchic regression model showed that disease severity explained 37.5% of the
variance in Schwab and England ADL score (P<.001). Gait hypokinesia and FOG
severity scores explained an additional 9.1% of the variance in activity
limitation (R(2) change=.091; P<.001). CONCLUSIONS: FOG severity and gait
hypokinesia were associated with reduced levels of activity after adjusting for
disease severity.
CI - Copyright (c) 2011 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS