Article

OBJECTIVE: To examine the temporal associations, within day and day to day,
between pain, fatigue, depressed mood, and cognitive function in multiple
sclerosis (MS). DESIGN: Repeated-measures study involving 7 days of ecological
momentary assessment (EMA) of symptoms 5 times a day; multilevel mixed models
were used to analyze data. SETTING: Community. PARTICIPANTS:
Ambulatory adults
(N=107) with MS. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE: EMA of
pain, fatigue, depressed mood, and cognitive function rated on a 0 to 10 scale.
RESULTS: Fatigue and pain were linked within day such that higher pain was
associated with higher subsequent fatigue (B=.09, P=.04); likewise, higher
fatigue was associated with higher pain in the following time frame (B=.05,
P=.04). Poorer perceived cognitive function preceded increased subsequent pain
(B=.08, P=.007) and fatigue (B=.10, P=.01) within day. Depressed mood was not
temporally linked with other symptoms. In terms of day-to-day effects, a day of
higher fatigue related to decreased next day fatigue (B=-.16, P=.01), and a day
of higher depressed mood related to increased depressed mood the next day (B=.17,
P=.01). There were no cross-symptom associations from one day to the next.
CONCLUSIONS: Findings provide new insights on how common symptoms in MS relate to
each other and vary within and over days. Pain and fatigue show evidence of a
dynamic bidirectional relation over the course of a day, and worsening of
perceived cognitive function preceded worsening of both pain and fatigue. Most
temporal associations between symptoms occur within the course of a day, with
relatively little carryover from one day to the next.
CI - Copyright (c) 2017 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS